MOTS-C

Description

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide that acts as a potent metabolic regulator to enhance insulin sensitivity, metabolic flexibility, and physical performance. It functions by activating the AMPK pathway and is explored for anti-aging, obesity treatment, and cellular stress resilience.

Key Characteristics and Functions:
•    Origin: Encoded by mitochondrial DNA (mtDNA), not nuclear DNA, acting as a signaling molecule between mitochondria and the nucleus.
•    Mechanism of Action: Activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy, to enhance glucose uptake and fatty acid oxidation.
•    Metabolic Impact: Improves insulin sensitivity, reduces fat accumulation in the liver, and increases mitochondrial function.
•    Anti-Aging and Performance: Studies show it can reverse age-dependent declines in physical capacity and is induced by exercise.
•    Target Tissues: Primarily acts on skeletal muscle, though it also impacts adipose tissue.

Common Uses in Research/Therapy:
•    Weight Management: Often researched for its ability to reduce obesity and improve metabolic health.
•    Diabetes Management: Helps regulate glucose metabolism, particularly in insulin resistance.
•    Anti-Aging: Promotes cellular resilience and energy homeostasis.